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Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
Colleen E. Clancy, … , Michihiro Tateyama, Robert S. Kass
Colleen E. Clancy, … , Michihiro Tateyama, Robert S. Kass
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1251-1262. https://doi.org/10.1172/JCI15928.
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Article Cardiology

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

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Abstract

Research Article

Authors

Colleen E. Clancy, Michihiro Tateyama, Robert S. Kass

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Figure 9

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Simulations predict that the burst mode dwell time, rather than latency ...
Simulations predict that the burst mode dwell time, rather than latency to burst, determines the stimulation-rate dependence of Isus. The figure illustrates the effect on Isus of changing the burst mode exit rates (open circles, 10–6 ms–1; dashes, 10–5 ms–1; filled diamonds, 10–4 ms–1) with fixed entry rates. In each panel, computations are shown for fast (interpulse interval, 20 milliseconds, left) and slow (interpulse interval, 1 second, right) stimulation rates (protocol described in Figure 8 legend). Isus at the end of each depolarization pulse (Isusn) is plotted as a percentage of Isus at the end of the first pulse (Isus1). The pulse-dependent reduction of Isus for each burst mode exit rate is unchanged regardless of the fixed entry rate (10–4 ms–1 in a, 10–5 ms–1 in b, and 10-6 ms–1 in c).

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