IL-12 is not required for clinical disease development. EAE was induced by active immunization of WT (diamonds), p35-/- (squares) and p40-/- (circles) mice with MOG35–55 emulsified in CFA. Clinical disease was monitored and statistical significance assessed using an unpaired Student’s t test. Each data point represents the mean of n animals in one experiment that was repeated at least two more times. #P < 0.05, *P < 0.01, comparison to WT mice.