Peer Wulff, Volker Vallon, Dan Yang Huang, Harald Völkl, Fang Yu, Kerstin Richter, Martina Jansen, Michaela Schlünz, Karin Klingel, Johannes Loffing, Gunther Kauselmann, Michael R. Bösl, Florian Lang, Dietmar Kuhl
Deficient adaptive response to low Na+ intake in sgk1–/– mice. (a) Urinary excretion of Na+ and water, and change in body weight in response to a low-NaCl diet (0 g Na+/kg) assessed in awake mice in metabolic cages (n = 6 each group). (b) Shown are mean arterial blood pressure and GFR in anesthetized mice on the control diet and at day 3 after initiating the low-NaCl diet (0.15 g Na+/kg) (n = 5–6 each group); and plasma aldosterone concentration in mice on control diet and at day 3 after initiating low-NaCl diet (0 g Na+/kg) (n = 8–9 each group). Filled circles and bars indicate sgk1–/– mice, open circles and bars indicate sgk1+/+ mice. *P < 0.05 versus sgk1+/+ mice.