T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1739-1747. https://doi.org/10.1172/JCI15695.
View: Text | PDF
Article Inflammation

T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase

Abstract

Research Article

Authors

Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett

×

Figure 4

Options: View larger image (or click on image) Download as PowerPoint
Time course of effect of anti-CD3 mAb on bioelectric parameters and inte...
Time course of effect of anti-CD3 mAb on bioelectric parameters and intestinal permeability of murine jejunum. Mice were injected with PBS (Sham-injected) or 0.2 mg anti-CD3 mAb at time 0. Jejunal sections were mounted in Ussing chambers for measurement of Isc, Gt, and Jmannitol. Values are means ± SE for 15 sections (eight mice) at 1 hour, eight sections (five mice) at 2 hours, and eight sections (four mice) at 3 hours. *P < 0.05, **P < 0.1 vs. sham-injected.