Cardiovascular physiology in Sur2^–/– mice. (a) Sur2^–/– mice exhibit decreased survival. Survival of littermate control and heterozygous mice (Sur2^+/+n = 15, 5 males and 10 females, and Sur2^+/–, n = 41, 12 males and 29 females), homozygous mutant females (Sur2^–/–, n = 18), and homozygous mutant males (Sur2^–/–, n = 17) as a function of age. (b) Telemetric blood pressure recordings of Sur2^–/– and normal littermate control mice. Representative blood pressure tracings from conscious, untethered control (Sur2^+/+) and homozygous mutant (Sur2^–/–) mice. (c) Systolic (white bars), diastolic (gray bars), and MAP (black bars) for littermate control and mutant mice (n = 6 and 4, respectively), recorded between days 2 and 4 after implantation. *P < 0.04, **P < 0.03, ***P < 0.02 versus normal littermate controls by two-tailed, unpaired Student t test. (d) Sur2^–/– mice do not respond to K_ATP vasoactive agents. Representative MAP tracings from a littermate control mouse (dotted line) and a Sur2^–/– mouse (solid line) during infusions of the agents indicated. Pinacidil was administered at 5 μg/kg/min and glibenclamide at 100 μg/kg/min. The interrupted line for glyburide infusion indicates the beginning of infusion for the normal control mouse (Sur2^+/+), while the mutant mouse (Sur2^–/–) infusion begins with the solid line.