Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1–infected patients with lipodystrophy
Georg M.N. Behrens, Anne-Rose Boerner, Klaus Weber, Joerg van den Hoff, Johann Ockenga, Georg Brabant, Reinhold E. Schmidt
Georg M.N. Behrens, Anne-Rose Boerner, Klaus Weber, Joerg van den Hoff, Johann Ockenga, Georg Brabant, Reinhold E. Schmidt
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Article Metabolism

Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1–infected patients with lipodystrophy

Abstract

Research Article

Authors

Georg M.N. Behrens, Anne-Rose Boerner, Klaus Weber, Joerg van den Hoff, Johann Ockenga, Georg Brabant, Reinhold E. Schmidt

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Differences in the distribution volume (DVCE) and the PF of F-18-FDG met...
Differences in the distribution volume (DVCE) and the PF of F-18-FDG metabolism. DVCE (left panel) reflects glucose transport, and PF (right panel) quantitatively describes the relative influence of glucose phosphorylation on the overall rate of glucose utilization. Both parameters were significantly higher in therapy-naive patients (white regions) than in patients with lipodystrophy on HAART (gray regions).