Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Hiroshi Yamamoto, … , Daniel J. Drucker, Joel K. Elmquist
Hiroshi Yamamoto, … , Daniel J. Drucker, Joel K. Elmquist
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):43-52. https://doi.org/10.1172/JCI15595.
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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

Abstract

Research Article

Authors

Hiroshi Yamamoto, Charlotte E. Lee, Jacob N. Marcus, Todd D. Williams, J. Michael Overton, Marisol E. Lopez, Anthony N. Hollenberg, Laurie Baggio, Clifford B. Saper, Daniel J. Drucker, Joel K. Elmquist

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EXN-4–activated neurons projecting to the spinal cord. A series of line ...
EXN-4–activated neurons projecting to the spinal cord. A series of line drawings demonstrates the distribution of Fos-IR (black circles), FG-IR (blue circles), and double-labeled (red stars) neurons in three rostral-to-caudal levels of the PVH (a–c), the Arc/RCA (d–f), and the LHA (g–i) of the hypothalamus after i.c.v. injection of EXN-4, in animals with FG injection into the spinal cord. Scale bar = 250 μm in a–c and 1,000 μm in d–i. Divisions of the PVH: dp, dorsal parvocellular; mp, medial parvocellular; pm, posterior magnocellular; vp, ventral parvocellular; lp, lateral parvicellular; ic, internal capsule. VMH, ventromedial nucleus of the hypothalamus; DMH, dorsomedial nucleus of the hypothalamus; ME, median eminence.