Osteoclasts are essential for TNF-α–mediated joint destruction
Kurt Redlich, Silvia Hayer, Romeo Ricci, Jean-Pierre David, Makiyeh Tohidast-Akrad, George Kollias, Günter Steiner, Josef S. Smolen, Erwin F. Wagner, Georg Schett
Kurt Redlich, Silvia Hayer, Romeo Ricci, Jean-Pierre David, Makiyeh Tohidast-Akrad, George Kollias, Günter Steiner, Josef S. Smolen, Erwin F. Wagner, Georg Schett
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Article Immunology

Osteoclasts are essential for TNF-α–mediated joint destruction

Abstract

Research Article

Authors

Kurt Redlich, Silvia Hayer, Romeo Ricci, Jean-Pierre David, Makiyeh Tohidast-Akrad, George Kollias, Günter Steiner, Josef S. Smolen, Erwin F. Wagner, Georg Schett

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Figure 1

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There are no differences in the clinical course of arthritis between hTN...
There are no differences in the clinical course of arthritis between hTNFtg and c-fos–/–hTNFtg mice. Clinical course of arthritis indicated by (a) joint swelling and (b) grip strength was assessed in wild-type mice (filled triangles), c-fos–/– mice (open circles), hTNFtg mice (open diamonds), and c-fos–/–hTNFtg mice (filled squares). Asterisks indicate a significant (P < 0.01) increase in joint swelling and decrease in grip strength in hTNFtg and c-fos–/–hTNFtg mice compared with baseline and with wild-type and c-fos–/– mice.