IFN-γ protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism
Karl-Johan Malmberg, Victor Levitsky, Håkan Norell, Cristina Teixeira de Matos, Mattias Carlsten, Kjell Schedvins, Hodjattallah Rabbani, Alessandro Moretta, Kalle Söderström, Jelena Levitskaya, Rolf Kiessling
Karl-Johan Malmberg, Victor Levitsky, Håkan Norell, Cristina Teixeira de Matos, Mattias Carlsten, Kjell Schedvins, Hodjattallah Rabbani, Alessandro Moretta, Kalle Söderström, Jelena Levitskaya, Rolf Kiessling
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Article Immunology

IFN-γ protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism

Abstract

Research Article

Authors

Karl-Johan Malmberg, Victor Levitsky, Håkan Norell, Cristina Teixeira de Matos, Mattias Carlsten, Kjell Schedvins, Hodjattallah Rabbani, Alessandro Moretta, Kalle Söderström, Jelena Levitskaya, Rolf Kiessling

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Figure 5

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Role of the HLA-G leader sequence peptide. OVAC 19 was incubated with di...
Role of the HLA-G leader sequence peptide. OVAC 19 was incubated with different concentrations of Gsp as indicated in the figure. HLA-A2–binding HIV peptide (HIV-RT 476-484) was used as negative control at 100 μg/ml. HIV- and Gsp-pulsed OVAC 19 was then used as target in a 4-hour 51Cr-release assay. The HLA class I–restricted, tumor-specific CTL line RF1 was used as effector. Results from one of two experiments are shown.