James O. Park, Carlos A. Lopez, Vinay K. Gupta, Charles K. Brown, Helena J. Mauceri, Thomas E. Darga, Abdullah Manan, Samuel Hellman, Mitchell C. Posner, Donald W. Kufe, Ralph R. Weichselbaum
In vivo measurement of TNF-α protein. TNF-α production by Ad.Egr.TNF.11D-injected xenografts was measured by ELISA. A significant increase in IT TNF-α protein concentration was observed following combined treatment with Ad.Egr.TNF.11D and cisplatin compared with treatment with Ad.Egr.TNF.11D vector alone in Seg-1 (a) (3.5-fold increase; P < 0.05) and PROb (b) xenografts (2.7-fold increase; P < 0.001). Data are reported as mean ± SEM.