Transcriptional control of viral gene therapy by cisplatin
James O. Park, … , Donald W. Kufe, Ralph R. Weichselbaum
James O. Park, … , Donald W. Kufe, Ralph R. Weichselbaum
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):403-410. https://doi.org/10.1172/JCI15548.
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Article Genetics

Transcriptional control of viral gene therapy by cisplatin

Abstract

Research Article

Authors

James O. Park, Carlos A. Lopez, Vinay K. Gupta, Charles K. Brown, Helena J. Mauceri, Thomas E. Darga, Abdullah Manan, Samuel Hellman, Mitchell C. Posner, Donald W. Kufe, Ralph R. Weichselbaum

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In vivo measurement of TNF-α protein. TNF-α production by Ad.Egr.TNF.11D...
In vivo measurement of TNF-α protein. TNF-α production by Ad.Egr.TNF.11D-injected xenografts was measured by ELISA. A significant increase in IT TNF-α protein concentration was observed following combined treatment with Ad.Egr.TNF.11D and cisplatin compared with treatment with Ad.Egr.TNF.11D vector alone in Seg-1 (a) (3.5-fold increase; P < 0.05) and PROb (b) xenografts (2.7-fold increase; P < 0.001). Data are reported as mean ± SEM.