Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival
Dinesh S. Rao, … , Martin G. Sanda, Theodora S. Ross
Dinesh S. Rao, … , Martin G. Sanda, Theodora S. Ross
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):351-360. https://doi.org/10.1172/JCI15529.
View: Text | PDF
Article Development

Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival

  • Text
  • PDF
Abstract

Research Article

Authors

Dinesh S. Rao, Teresa S. Hyun, Priti D. Kumar, Ikuko F. Mizukami, Mark A. Rubin, Peter C. Lucas, Martin G. Sanda, Theodora S. Ross

×

Figure 5

Options: View larger image (or click on image) Download as PowerPoint
Relationship of HIP1 expression with clinical outcome. A tissue microarr...
Relationship of HIP1 expression with clinical outcome. A tissue microarray derived from prostatic tumors surgically resected from 121 patients and a tissue microarray derived from hormone-refractory metastatic prostate cancer from 15 patients were used. (a) Analysis of HIP1 expression in individual patients showed that there were progressively higher frequencies of HIP1 expression in benign (n = 89), PIN (n = 89), prostate-confined prostate cancer (n = 114), and metastatic cases (n = 14). These differences are statistically significant (Pearson’s χ-squared, P < 0.001), and the presence of HIP1 expression correlated significantly with the ordinal categories of benign, PIN, prostate cancer, and metastatic (Spearman’s correlation coefficient, 0.664, P < 0.001). (b) Kaplan-Meier survival analysis illustrates progression-free survival after radical prostatectomy stratified by prostate-confined tumors that did not express HIP1 (circles) with tumors that did express HIP1 (triangles). Tumors that had zero HIP1 staining (n = 14, circles) did not have a prostate cancer recurrence. On the other hand, 28% of patients with HIP1 staining (n = 100) went on to relapse.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts