The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
Jennifer M. McCoy, … , Joan R. Wicks, Laurent P. Audoly
Jennifer M. McCoy, … , Joan R. Wicks, Laurent P. Audoly
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):651-658. https://doi.org/10.1172/JCI15528.
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Article Genetics

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

Abstract

Research Article

Authors

Jennifer M. McCoy, Joan R. Wicks, Laurent P. Audoly

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Figure 1

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Development of arthritis in EP receptor–deficient animals. (a) Severity ...
Development of arthritis in EP receptor–deficient animals. (a) Severity of arthritis. Mice bearing targeted mutations for each of the individual EP receptors were tested for their ability to develop clinical signs of arthritis. Paws from each mouse were scored on day 10 as described in Methods. EP1+/+, n = 7; EP1–/–, n = 10; EP2+/+, n = 10; EP2–/–, n = 10; EP3+/+, n = 8; EP3–/–, n = 8; EP4+/+, n = 24; EP4–/–, n = 23. *P < 0.05 by Mann-Whitney U test. (b) Incidence of arthritis. *P < 0.05 by χ-square test.