Stephan Fellner, Björn Bauer, David S. Miller, Martina Schaffrik, Martina Fankhänel, Thilo Spruß, Günther Bernhardt, Claudia Graeff, Lothar Färber, Harald Gschaidmeier, Armin Buschauer, Gert Fricker
Effect of valspodar/paclitaxel coadministration on the intracerebral growth of the human U 118 MG glioblastoma in nude mice. Controls received no medication, the paclitaxel group received the vehicle of valspodar 4 hours before injection of paclitaxel, and the paclitaxel-valspodar group received 50 mg/kg valspodar by mouth before injection of paclitaxel. Animals were treated in this way on day 8 (3 mg/kg paclitaxel) and day 15 (2 mg/kg paclitaxel) after implantation of tumors. Thirty-five days after tumor implantation the brains of the animals were collected and the tumor volumes determined morphometrically. The figure shows mean values ± SEM (n = 5). Inset: Change of mean body weight as an indicator of toxicity. Control, open squares; paclitaxel, open circles; paclitaxel-valspodar, filled squares. The arrows indicate drug administration.