Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
Stephan Fellner, Björn Bauer, David S. Miller, Martina Schaffrik, Martina Fankhänel, Thilo Spruß, Günther Bernhardt, Claudia Graeff, Lothar Färber, Harald Gschaidmeier, Armin Buschauer, Gert Fricker
Stephan Fellner, Björn Bauer, David S. Miller, Martina Schaffrik, Martina Fankhänel, Thilo Spruß, Günther Bernhardt, Claudia Graeff, Lothar Färber, Harald Gschaidmeier, Armin Buschauer, Gert Fricker
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Article Oncology

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

Abstract

Research Article

Authors

Stephan Fellner, Björn Bauer, David S. Miller, Martina Schaffrik, Martina Fankhänel, Thilo Spruß, Günther Bernhardt, Claudia Graeff, Lothar Färber, Harald Gschaidmeier, Armin Buschauer, Gert Fricker

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(a) Time-dependent accumulation of BODIPY Fl-paclitaxel in cells and lum...
(a) Time-dependent accumulation of BODIPY Fl-paclitaxel in cells and lumens of isolated rat brain capillaries in the absence and presence of 1 mM NaCN. Means ± SEM, n = 10–12, P = 0.05. (b) Accumulation of BODIPY Fl-paclitaxel and NBDL-CS (c), respectively, in the lumens of isolated capillaries in the absence and presence of unlabeled paclitaxel, the p-gp blocker valspodar, and the mrp2 substrate LTC4. The fluorescent compounds were added at concentrations of 1 μM. Means ± SEM, n = 10–12. *Significantly different from controls; P = 0.05.