Effects of IFN-α/β on susceptibility to MCMV. Livers were harvested and H&E-stained sections were prepared from 129-IFN-α/βR– mice infected with 5 × 104 PFU MCMV for 48 (a) or 72 (b) hours. Arrows denote a liver area with cytomegalic inclusion bodies, and the arrowhead in b represents an area of tissue necrosis. The inset shows cytomegalic inclusion bodies at a higher magnification. Images were digitally captured at the original magnifications of ×10 and ×40. Scale bars = 100 μm. (c) The 129-IFN-α/βR+ and 129-IFN-α/βR– mice were uninfected or infected with 1 × 104 PFU MCMV and monitored twice daily for survival (n = 6).