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Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver
Thais P. Salazar-Mather, … , Casey A. Lewis, Christine A. Biron
Thais P. Salazar-Mather, … , Casey A. Lewis, Christine A. Biron
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):321-330. https://doi.org/10.1172/JCI15376.
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Article Immunology

Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver

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Abstract

Research Article

Authors

Thais P. Salazar-Mather, Casey A. Lewis, Christine A. Biron

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Figure 1

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NK cell accumulation in MCMV-infected C57BL/6 and 129 livers. Livers wer...
NK cell accumulation in MCMV-infected C57BL/6 and 129 livers. Livers were harvested and H&E-stained tissue sections were prepared from C57BL/6 (a) or 129 (b) mice infected with MCMV for 48 hours as described in Methods. Arrows in a and b denote inflammatory foci. Images were digitally captured at the original magnifications of ×10. Scale bar = 100 μm. (c–f) Liver leukocytes were prepared from C57BL/6 (c and d) or 129 (e and f) mice that were uninfected (0 hours) or infected with MCMV for 48 hours. Leukocytes were analyzed by flow cytometry as described in Methods. Both the percentage (c and e) and number (d and f) of NK1.1+TCR-β– or DX5+TCR-β– cells per g liver are shown. Data are the means ± SE (n = 3–6). Differences between uninfected and infected mice are significant at *P ≤ 0.03 and **P < 0.001.

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