Collagen-binding integrin α1β1 regulates intestinal inflammation in experimental colitis
Christian F. Krieglstein, Wolfgang H. Cerwinka, Andrew G. Sprague, F. Stephen Laroux, Matthew B. Grisham, Victor E. Koteliansky, Norbert Senninger, D. Neil Granger, Antonin R. de Fougerolles
Christian F. Krieglstein, Wolfgang H. Cerwinka, Andrew G. Sprague, F. Stephen Laroux, Matthew B. Grisham, Victor E. Koteliansky, Norbert Senninger, D. Neil Granger, Antonin R. de Fougerolles
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Article Immunology

Collagen-binding integrin α1β1 regulates intestinal inflammation in experimental colitis

Abstract

Research Article

Authors

Christian F. Krieglstein, Wolfgang H. Cerwinka, Andrew G. Sprague, F. Stephen Laroux, Matthew B. Grisham, Victor E. Koteliansky, Norbert Senninger, D. Neil Granger, Antonin R. de Fougerolles

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Figure 1

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Treatment with anti-α1 mAb prevents DSS-mediated colitis. Mice were fed ...
Treatment with anti-α1 mAb prevents DSS-mediated colitis. Mice were fed DSS over 7 days and treated with mAb (control or anti-α1) every second day starting at day 0. Disease severity was measured daily and is expressed in terms of (a) body weight, (b) fecal blood, (c) diarrhea, and (d) disease activity index (combined index of a + b + c). The isotype mAb-treated group exhibited no significant differences from WT mice receiving DSS alone (see Figure 2). *P < 0.05; anti-α1 mAb vs. isotype mAb. Data represent mean ± SEM.