c-Rel and NF-κB1 regulate different types of T cell responses. C57BL/6 or B6;129 mice were treated and tested as for Figure 3. Data presented are IFN-γ and IL-4 concentrations of splenocyte cultures activated with 25 μg/ml of MOG peptide. Control C57BL/6 culture (open circle), control B6;129 culture (open square), c-Rel–/– C57BL/6 culture (filled circle), and NF-κB1–/– B6;129 culture (filled square).