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1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Yan Chun Li, … , Shu Q. Liu, Li-Ping Cao
Yan Chun Li, … , Shu Q. Liu, Li-Ping Cao
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):229-238. https://doi.org/10.1172/JCI15219.
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Article

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

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Abstract

Research Article

Authors

Yan Chun Li, Juan Kong, Minjie Wei, Zhou-Feng Chen, Shu Q. Liu, Li-Ping Cao

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Figure 8

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1,25(OH)2D3 suppresses renin gene transcription. (a) Expression of hVDR ...
1,25(OH)2D3 suppresses renin gene transcription. (a) Expression of hVDR mRNA in stable As4.1 clones. P, parental As4.1 cells; #57, As4.1 clone 57 stably transfected with pcDNA-hVDR; V, As4.1 clone stably transfected with the empty vector pcDNA3.1. (b) Renin mRNA expression in As4.1 clone V (Vector) and #57 treated with ethanol (E) or different doses of 1,25(OH)2D3 as indicated. (c) As4.1-hVDR cells (clone #57) were transfected with pGL3-control, pGL-4.1kb, or pGL-117bp luciferase reporter plasmid and then treated with ethanol (black bars) or 10–8 M 1,25(OH)2D3 (white bars). Luciferase activity was determined 48 hours after transfection. Similar results were obtained in other stable clones (data not shown).
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