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1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Yan Chun Li, … , Shu Q. Liu, Li-Ping Cao
Yan Chun Li, … , Shu Q. Liu, Li-Ping Cao
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):229-238. https://doi.org/10.1172/JCI15219.
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Article

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

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Abstract

Research Article

Authors

Yan Chun Li, Juan Kong, Minjie Wei, Zhou-Feng Chen, Shu Q. Liu, Li-Ping Cao

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Figure 7

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Suppression of renin mRNA expression by 1,25(OH)2D3 in As4.1 cells. (a) ...
Suppression of renin mRNA expression by 1,25(OH)2D3 in As4.1 cells. (a) As4.1 cells were transiently transfected with (+) or without (–) pcDNA-hVDR plasmid containing the full-length human VDR cDNA and then treated with 5 × 10–8 M 1,25(OH)2D3 (+) or ethanol (–) for 24 hours. Total cellular RNA was isolated and analyzed by Northern blot with renin and 36B4 cDNA probes. (b) Quantitative results of Northern blot analyses obtained from three independent experiments. C, ethanol-treated; VD, 1,25(OH)2D3-treated; T, transfected with pcDNA-hVDR and treated with ethanol; T/VD, transfected with pcDNA-hVDR and treated with 1,25(OH)2D3. *P < 0.001 vs. C, VD, or T value. (c) Renin mRNA expression in As4.1 cells (left panel), and in As4.1 cells transfected with pcDNA-PTH/PTHrPR containing the rat PTH/PTHrP receptor cDNA (right panel) and treated with bovine PTH(1–34) as indicated. –, untreated.
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