Effect of VDR inactivation on blood pressure and heart weight/body weight ratio. (a) Systolic and diastolic blood pressures of wild-type (white bars) and VDR^–/– (black bars) mice. *P < 0.01 vs. corresponding wild-type mice; n = 9 for wild-type mice; n = 8 for VDR^–/– mice. (b) Ratio of heart weight to body weight of wild-type and VDR^–/– mice. *P < 0.05 vs. wild-type mice; n = 9 in each genotype. (c) Mean blood pressure (BP) of wild-type (white bars) and VDR^–/– (black bars) mice untreated or treated with captopril for 5 days. *P < 0.05 vs. corresponding untreated wild-type mice; n = 4 in each genotype in each group.