Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice
Masanori Ozaki, … , Masahiro Masada, Mitsuhiro Yokoyama
Masanori Ozaki, … , Masahiro Masada, Mitsuhiro Yokoyama
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):331-340. https://doi.org/10.1172/JCI15215.
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Article Vascular biology

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

Abstract

Research Article

Authors

Masanori Ozaki, Seinosuke Kawashima, Tomoya Yamashita, Tetsuaki Hirase, Masayuki Namiki, Nobutaka Inoue, Ken-ichi Hirata, Hiroyuki Yasui, Hiromu Sakurai, Yuichi Yoshida, Masahiro Masada, Mitsuhiro Yokoyama

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Figure 2

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Histological examination of atherosclerotic lesions in the aortic root. ...
Histological examination of atherosclerotic lesions in the aortic root. (a and b) Photographs are representative of immunostaining for MOMA-2 in the atherosclerotic lesions, which showed no difference in the distribution between apoE-KO (a) and apoE-KO/eNOS-Tg mice (b) fed on a high-cholesterol diet for 8 weeks. (c and d) Fibrotic changes were detected with Masson’s trichrome in the aortic root sections from apoE-KO (c) and apoE-KO/eNOS-Tg mice (d) fed a high-cholesterol diet. Fibrosis was only partly distributed in the plaque lesions of both mice (original magnification ×75).