Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
Lianchun Wang, Jillian R. Brown, Ajit Varki, Jeffrey D. Esko
Lianchun Wang, Jillian R. Brown, Ajit Varki, Jeffrey D. Esko
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Article Vascular biology

Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

Abstract

Research Article

Authors

Lianchun Wang, Jillian R. Brown, Ajit Varki, Jeffrey D. Esko

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Inhibition of U937 cell adhesion to activated human lung microvascular e...
Inhibition of U937 cell adhesion to activated human lung microvascular endothelial cells by modified heparins. Inclusion of a mAb to P-selectin or EDTA blocked binding by more than 90%. Each point represents the average of duplicate determinations, and the data are representative of three or four separate experiments.