The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner
Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner
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Article Genetics

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

Abstract

Research Article

Authors

Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner

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Pressure overload in MEKK1–/– mice caused increases in the lung/body wei...
Pressure overload in MEKK1–/– mice caused increases in the lung/body weight and LV end-diastolic dimension and decreases in LVEF. Aortic banding or sham operation was applied in control or MEKK1–/– mice. (a) The lung weight and the body weight were determined at 14 days. (b and c) Echocardiographic measurements were performed at 14 days. LVEDD and LVEF were determined.