Pressure overload in MEKK1–/– mice caused increases in the lung/body weight and LV end-diastolic dimension and decreases in LVEF. Aortic banding or sham operation was applied in control or MEKK1–/– mice. (a) The lung weight and the body weight were determined at 14 days. (b and c) Echocardiographic measurements were performed at 14 days. LVEDD and LVEF were determined.