Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
Zhonghua Qi, … , Jason D. Morrow, Matthew D. Breyer
Zhonghua Qi, … , Jason D. Morrow, Matthew D. Breyer
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):61-69. https://doi.org/10.1172/JCI14752.
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Article Vascular biology

Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II

Abstract

Research Article

Authors

Zhonghua Qi, Chuan-Ming Hao, Robert I. Langenbach, Richard M. Breyer, Reyadh Redha, Jason D. Morrow, Matthew D. Breyer

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Effect of Ang II infusion and COX1 and COX2 deficiency on renal medullar...
Effect of Ang II infusion and COX1 and COX2 deficiency on renal medullary PGE2 and PGI2 synthesis. Prostanoids were measured by gas chromatography/mass spectrscopy in snap-frozen papillae dissected from mice pretreated with the COX2 inhibitor (COX2 inh.), vehicle-treated mice, or COX knockout mice with or without acute infusion of Ang II for 30 minutes. *P < 0.01 and #P < 0.05 vs. control.