(a) Upregulation of the activation markers (CD44high, CD45RBlow, Mel-14low) in LNCs gated on CD4 from Clik60-treated mice, compared with control mice. (b) SS model mice treated with Clik60 showed a significant decrease of autoantigen-specific (JS-1–specific) T cell proliferation in LNCs, compared with controls (P < 0.01, Student’s t test). Data are expressed as cpm per culture in triplicate.