Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity
Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Rieko Arakaki, Kouichi Ogawa, Ichiro Saito, Nobuhiko Katunuma, Yoshio Hayashi
Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Rieko Arakaki, Kouichi Ogawa, Ichiro Saito, Nobuhiko Katunuma, Yoshio Hayashi
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Article Immunology

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

Abstract

Research Article

Authors

Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Rieko Arakaki, Kouichi Ogawa, Ichiro Saito, Nobuhiko Katunuma, Yoshio Hayashi

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(a) Upregulation of the activation markers (CD44high, CD45RBlow, Mel-14l...
(a) Upregulation of the activation markers (CD44high, CD45RBlow, Mel-14low) in LNCs gated on CD4 from Clik60-treated mice, compared with control mice. (b) SS model mice treated with Clik60 showed a significant decrease of autoantigen-specific (JS-1–specific) T cell proliferation in LNCs, compared with controls (P < 0.01, Student’s t test). Data are expressed as cpm per culture in triplicate.