Sophie Lanone, Tao Zheng, Zhou Zhu, Wei Liu, Chun Geun Lee, Bing Ma, Qingsheng Chen, Robert J. Homer, Jingming Wang, Lesley A. Rabach, Morgan E. Rabach, J. Michael Shipley, Steven D. Shapiro, Robert M. Senior, Jack A. Elias
Survival and terminal pathology of CC10-IL-13 mice and littermate control mice with wild-type and null MMP loci. (a) The effects of MMP-9 deficiency on survival. (b) The effects of MMP-12 deficiency on survival. In a and b comparisons are made of the survival of transgene– mice with wild-type (squares) and null (triangles) MMP loci and transgene+ mice with wild-type (diamonds) and null (circles) MMP loci. Each point represents the survival of a minimum of six animals. (c) The airway and parenchymal abnormalities in lungs from near-terminal 4-month-old IL-13+/MMP-12+/+ mice and 6.5-month-old IL-13+/MMP-12–/– mice.