Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
Sophie Lanone, … , Robert M. Senior, Jack A. Elias
Sophie Lanone, … , Robert M. Senior, Jack A. Elias
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):463-474. https://doi.org/10.1172/JCI14136.
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Article Immunology

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

Abstract

Research Article

Authors

Sophie Lanone, Tao Zheng, Zhou Zhu, Wei Liu, Chun Geun Lee, Bing Ma, Qingsheng Chen, Robert J. Homer, Jingming Wang, Lesley A. Rabach, Morgan E. Rabach, J. Michael Shipley, Steven D. Shapiro, Robert M. Senior, Jack A. Elias

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Survival and terminal pathology of CC10-IL-13 mice and littermate contro...
Survival and terminal pathology of CC10-IL-13 mice and littermate control mice with wild-type and null MMP loci. (a) The effects of MMP-9 deficiency on survival. (b) The effects of MMP-12 deficiency on survival. In a and b comparisons are made of the survival of transgene– mice with wild-type (squares) and null (triangles) MMP loci and transgene+ mice with wild-type (diamonds) and null (circles) MMP loci. Each point represents the survival of a minimum of six animals. (c) The airway and parenchymal abnormalities in lungs from near-terminal 4-month-old IL-13+/MMP-12+/+ mice and 6.5-month-old IL-13+/MMP-12–/– mice.