Sophie Lanone, Tao Zheng, Zhou Zhu, Wei Liu, Chun Geun Lee, Bing Ma, Qingsheng Chen, Robert J. Homer, Jingming Wang, Lesley A. Rabach, Morgan E. Rabach, J. Michael Shipley, Steven D. Shapiro, Robert M. Senior, Jack A. Elias
Effect of MMP-9 deficiency on BAL chemokine accumulation. CC10-rtTA-IL-13 transgene– and transgene+ mice with wild-type and null MMP-9 loci were placed on dox water at 1 month of age and maintained on dox water for an additional 10–60 days as noted. The levels of BAL KC (a), MIP-2 (b), and MCP-1 (c) protein were assessed by ELISA. Circles, CC10-rtTA-IL-13+/MMP-9–/–; diamonds, CC10-rtTA-IL-13+/MMP-9+/+; squares, CC10-rtTA-IL-13–/MMP-9+/+. Note that the levels of chemokines in BAL fluids from CC10-rtTA-IL-13 transgene– mice with null and wild-type MMP-9 loci are superimposed in these graphs. The noted values represent the mean ± SEM of a minimum of six animals at each time point (*P < 0.01).