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Usage Information

SARS-CoV-2: a storm is raging
Savannah F. Pedersen, Ya-Chi Ho
Savannah F. Pedersen, Ya-Chi Ho
Published March 27, 2020
Citation Information: J Clin Invest. 2020;130(5):2202-2205. https://doi.org/10.1172/JCI137647.
View: Text | PDF
Commentary

SARS-CoV-2: a storm is raging

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Abstract

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.

Authors

Savannah F. Pedersen, Ya-Chi Ho

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 2,391 174
PDF 312 38
Figure 183 5
Citation downloads 148 0
Totals 3,034 217
Total Views 3,251
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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