Effects of noggin, a Bmp-binding protein, on Caco2 colony morphology in myofibroblast-Caco2 cocultured cells. Epimorphin-transfected myofibroblasts were incubated with media containing noggin (1 μg/ml) or with control media, and Caco2 cells were plated onto the myofibroblasts. Cocultures were treated with noggin-containing or control media for 3 days and photomicrographs were obtained. (a) Control vehicle treatment. (b) Noggin-treated cocultures. Arrows depict Caco2 colonies. Magnification:×100.