Go to
JCI Insight
Figure 1
The remarkable resistance of humans (and mammals) to fungal diseases rests on the two pillars of advanced immunity and endothermy (i.e., the state of being warm-blooded).
Options:
View larger image
(or click on image)
Download as PowerPoint
Immune suppression or climate change with microbial adaptation to survive at higher temperatures can undermine these pillars and make the host vulnerable to fungal disease.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)