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Usage Information

Immunotherapy of multiple myeloma
Simone A. Minnie, Geoffrey R. Hill
Simone A. Minnie, Geoffrey R. Hill
Published March 9, 2020
Citation Information: J Clin Invest. 2020;130(4):1565-1575. https://doi.org/10.1172/JCI129205.
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Review Series

Immunotherapy of multiple myeloma

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Abstract

Multiple myeloma (MM), a bone marrow–resident hematological malignancy of plasma cells, has remained largely incurable despite dramatic improvements in patient outcomes in the era of myeloma-targeted and immunomodulatory agents. It has recently become clear that T cells from MM patients are able to recognize and eliminate myeloma, although this is subverted in the majority of patients who eventually succumb to progressive disease. T cell exhaustion and a suppressive bone marrow microenvironment have been implicated in disease progression, and once these are established, immunotherapy appears largely ineffective. Autologous stem cell transplantation (ASCT) is a standard of care in eligible patients and results in immune effects beyond cytoreduction, including lymphodepletion, T cell priming via immunogenic cell death, and inflammation; all occur within the context of a disrupted bone marrow microenvironment. Recent studies suggest that ASCT reestablishes immune equilibrium and thus represents a logical platform in which to intervene to prevent immune escape. New immunotherapies based on checkpoint inhibition targeting the immune receptor TIGIT and the deletion of suppressive myeloid populations appear attractive, particularly after ASCT. Finally, the immunologically favorable environment created after ASCT may also represent an opportunity for approaches utilizing bispecific antibodies or chimeric antigen receptor T cells.

Authors

Simone A. Minnie, Geoffrey R. Hill

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 3,076 1,602
PDF 281 410
Figure 300 6
Citation downloads 106 0
Totals 3,763 2,018
Total Views 5,781
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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