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Usage Information

Cellular therapy against public neoantigens
Paul M. Armistead
Paul M. Armistead
Published January 14, 2019
Citation Information: J Clin Invest. 2019;129(2):506-508. https://doi.org/10.1172/JCI126116.
View: Text | PDF
Commentary

Cellular therapy against public neoantigens

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Abstract

Neoantigen-targeted therapies have typically been based upon personalized neoantigen-specific vaccines; however, in this issue of JCI, van der Lee et al. describe the development of a potential cellular immunotherapy targeting a “public” neoantigen derived from nucleophosmin 1 (NPM1), which is mutated in approximately 30% of acute myeloid leukemias (AMLs). The authors use reverse immunology to predict, and biochemically confirm, NPM1-derived neoepitopes (ΔNPM1) and then generate high-avidity T cell clones and retrovirally transduced T cell populations that kill NPM1-mutated AML. This study provides a general approach to adoptive cellular therapy that can be applied to targeting other tumors with public neoantigens.

Authors

Paul M. Armistead

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