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Colorectal cancer: the APC-lncRNA link
Pat J. Morin
Pat J. Morin
Published January 14, 2019
Citation Information: J Clin Invest. 2019;129(2):503-505. https://doi.org/10.1172/JCI125985.
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Commentary

Colorectal cancer: the APC-lncRNA link

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Abstract

The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in the regulation of cell proliferation and survival through its ability to regulate canonical Wnt signaling. In this issue of the JCI, Wang et al. provide an intriguing new mechanism for APC function involving the regulation of a novel long noncoding RNA (lncRNA), leading to changes in exosome production. APC signaling via this novel pathway can regulate cell proliferation and invasion as well as angiogenesis. In addition to enhancing our understanding of APC function, this new mechanism is of particular clinical significance, as it may provide additional targets for the treatment of APC-mutated cancers.

Authors

Pat J. Morin

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Figure 1

Summary of pathways and functions attributed to APC.

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Summary of pathways and functions attributed to APC.

Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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