Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Aging (Upcoming)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Mitochondrial transplantation in humans: “magical” cure or cause for concern?
Edoardo Bertero, … , Christoph Maack, Brian O’Rourke
Edoardo Bertero, … , Christoph Maack, Brian O’Rourke
Published October 29, 2018
Citation Information: J Clin Invest. 2018;128(12):5191-5194. https://doi.org/10.1172/JCI124944.
View: Text | PDF
Viewpoint

Mitochondrial transplantation in humans: “magical” cure or cause for concern?

  • Text
  • PDF
Abstract

Authors

Edoardo Bertero, Christoph Maack, Brian O’Rourke

×

Figure 1

The proposed mechanism of action of mitochondrial transplantation in myocardial ischemia requires that the mitochondria perform three “magic tricks,” which raises several critical questions.

Options: View larger image (or click on image) Download as PowerPoint
The proposed mechanism of action of mitochondrial transplantation in myo...
(i) For trick number one, the mitochondria must survive transfer from an intracellular environment to an extracellular one. This raises the question of how mitochondria survive high extracellular Ca2+ concentrations. (ii) For trick number two, mitochondria must produce ATP to support contraction. We ask: how can extracellular mitochondria produce ATP and how can extracellular ATP support contraction? (iii) For trick number three, a sufficient number of mitochondria must pass through the cell membrane to contribute to ATP production by the host cell. This prompts the questions of whether and how viable mitochondria actually enter myocytes and cross endothelial/vascular barriers, and do enough mitochondria do so to make a difference for ATP production?

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts