Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Lung inflammatory injury and tissue repair (Jul 2023)
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival
Steven R. Duncan, … , Brian R. Lawson, Argyrios N. Theofilopoulos
Steven R. Duncan, … , Brian R. Lawson, Argyrios N. Theofilopoulos
Published March 15, 2002
Citation Information: J Clin Invest. 2002;109(6):755-764. https://doi.org/10.1172/JCI12142.
View: Text | PDF
Article

Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival

  • Text
  • PDF
Abstract

We have demonstrated that murine thymic dendritic cells (DCs) isolated from donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous injections, where they induce T cell deletions and prolong donor-strain airway and skin graft survival. In contrast, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival. These findings suggest that preferential homing may be an important mechanistic difference among subpopulations of DCs that mediate immune functions and illustrate a novel methodology that could have utility for induction of specific immunologic nonreactivity to allografts, or other disease-associated antigens.

Authors

Steven R. Duncan, Nickolas G. Capetanakis, Brian R. Lawson, Argyrios N. Theofilopoulos

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Phenotypes of TDCs and SDCs. Frequencies versus log10 fluorescence inten...
Phenotypes of TDCs and SDCs. Frequencies versus log10 fluorescence intensities of the markers are depicted by the white profile. The gray profile indicates background staining. Results shown are representative of 6 or more experiments with similar results.

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts