Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

R C Bargou; F Emmerich; D Krappmann; K Bommert; M Y Mapara; W Arnold; H D Royer; E Grinstein; A Greiner; C Scheidereit; B Dörken

doi:10.1172/JCI119849

Max Delbr-uck Center for Molecular Medicine, 13122 Berlin, Germany.

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Published in Volume 100, Issue 12 on December 15, 1997
J Clin Invest. 1997;100(12):2961–2969. https://doi.org/10.1172/JCI119849.
© 1997 The American Society for Clinical Investigation

Published December 15, 1997 - Version history

The pathogenesis and etiology of Hodgkin's disease, a common human malignant lymphoma, is still unresolved. As a unique characteristic, we have identified constitutive activation of the transcription factor nuclear factor (NF)-kappaB p50-RelA in Hodgkin/Reed-Sternberg (H/RS) cells, which discriminates these neoplastic cells from most cell types studied to date. In contrast to other lymphoid and nonlymphoid cell lines tested, proliferation of H/RS cells depended on activated NF-kappaB. Furthermore, constitutive NF-kappaB p50-RelA prevented Hodgkin's lymphoma cells from undergoing apoptosis under stress conditions. Consistent with this dual function, Hodgkin's lymphoma cells depleted of constitutive nuclear NF-kappaB revealed strongly impaired tumor growth in severe combined immunodeficient mice. Our findings identify NF-kappaB as an important component for understanding the pathogenesis of Hodgkin's disease and for developing new therapeutic strategies against it.

Version 1 (December 15, 1997): No description

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

R C Bargou, F Emmerich, D Krappmann, K Bommert, M Y Mapara, W Arnold, H D Royer, E Grinstein, A Greiner, C Scheidereit, and B Dörken

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

R C Bargou, F Emmerich, D Krappmann, K Bommert, M Y Mapara, W Arnold, H D Royer, E Grinstein, A Greiner, C Scheidereit, and B Dörken

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