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Research Article Free access | 10.1172/JCI119082

Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis.

M Boirivant, R Pica, R DeMaria, R Testi, F Pallone, and W Strober

Immunology Department, Istituto Superiore di Sanità, Rome, Italy.

Find articles by Boirivant, M. in: JCI | PubMed | Google Scholar

Immunology Department, Istituto Superiore di Sanità, Rome, Italy.

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Immunology Department, Istituto Superiore di Sanità, Rome, Italy.

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Immunology Department, Istituto Superiore di Sanità, Rome, Italy.

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Immunology Department, Istituto Superiore di Sanità, Rome, Italy.

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Immunology Department, Istituto Superiore di Sanità, Rome, Italy.

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Published December 1, 1996 - More info

Published in Volume 98, Issue 11 on December 1, 1996
J Clin Invest. 1996;98(11):2616–2622. https://doi.org/10.1172/JCI119082.
© 1996 The American Society for Clinical Investigation
Published December 1, 1996 - Version history
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Abstract

Lamina propria (LP) T cells respond poorly to a proliferative stimulus delivered via TCR/CD3 pathway, but retain considerable ability to respond to a stimulus delivered via CD2 costimulatory or accessory pathway. In the present study, we showed first that unstimulated LP T cells, as compared to unstimulated peripheral blood (PB) T cells, exhibit an increased level of apoptosis which is further increased following CD2 pathway stimulation, but not following via TCR/CD3 pathway stimulation. We next showed that IL-2 had a sparing effect on apoptosis of unstimulated LP T cells in that IL-2 decreased and anti-IL-2 increased apoptosis of these cells; in contrast, IL-2 had no effect on apoptosis of CD2-pathway stimulated cells. Finally, we showed that increased apoptosis of LP T cells induced by CD2-pathway stimulation is inhibited when Fas antigen is blocked by a nonstimulatory anti-Fas antibody. These studies suggest that LP T cells are characterized by increased susceptibility to Fas-mediated apoptosis most due to a downstream change in the Fas signaling pathway. Given that IFN-gamma secretion is significantly increased in LP T cells in which apoptosis is inhibited, this feature of LP T cells may represent a mechanism of regulating detrimental immune responses in the mucosal environment.

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