Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI119000

Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver.

M Véniant, J Ménard, P Bruneval, S Morley, M F Gonzales, and J Mullins

Centre for Genome Research, Edinburgh, United Kingdom. Murielle_Veniant.gicd@quickmail.ucsf.edu

Find articles by Véniant, M. in: PubMed | Google Scholar

Centre for Genome Research, Edinburgh, United Kingdom. Murielle_Veniant.gicd@quickmail.ucsf.edu

Find articles by Ménard, J. in: PubMed | Google Scholar

Centre for Genome Research, Edinburgh, United Kingdom. Murielle_Veniant.gicd@quickmail.ucsf.edu

Find articles by Bruneval, P. in: PubMed | Google Scholar

Centre for Genome Research, Edinburgh, United Kingdom. Murielle_Veniant.gicd@quickmail.ucsf.edu

Find articles by Morley, S. in: PubMed | Google Scholar

Centre for Genome Research, Edinburgh, United Kingdom. Murielle_Veniant.gicd@quickmail.ucsf.edu

Find articles by Gonzales, M. in: PubMed | Google Scholar

Centre for Genome Research, Edinburgh, United Kingdom. Murielle_Veniant.gicd@quickmail.ucsf.edu

Find articles by Mullins, J. in: PubMed | Google Scholar

Published November 1, 1996 - More info

Published in Volume 98, Issue 9 on November 1, 1996
J Clin Invest. 1996;98(9):1966–1970. https://doi.org/10.1172/JCI119000.
© 1996 The American Society for Clinical Investigation
Published November 1, 1996 - Version history
View PDF
Abstract

We have developed a transgenic animal model to investigate the effects of overexpression of rat prorenin on the cardiovascular system. Two transgenic rat lines were generated in which rat prorenin expression was directed to the liver by a human alpha1-antitrypsin promoter. Liver-specific expression was confirmed by RNase protection assay. Plasma prorenin concentrations in transgenic rats were increased 400-fold in the males of both lines but were increased only two- to threefold in the females. Thus, transgene expression exhibited sexual dimorphism. Blood pressures were not significantly higher in transgenic rats than in nontransgenic controls. The ratio of heart weight to body weight was greater in male transgenic rats than in the nontransgenic controls. Histological analysis revealed severe renal lesions and hypertrophic cardiomyocytes in transgenic males only. This transgenic model demonstrates a likely role of prorenin in the development of cardiac and renal pathology independent of hypertension. These animals will facilitate studies of the effects of blockade of the renin-angiotensin system and other pharmacological interventions on the development and treatment of cardiac, vascular, and renal lesions induced by changes in this system in the absence of chronic hypertension.

Version history
  • Version 1 (November 1, 1996): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts