Advertisement

Research Article Free access | 10.1172/JCI118979

Human immunodeficiency virus-1 (HIV-1) gp120 superantigen-binding serum antibodies. A host factor in homosexual HIV-1 transmission.

J Townsley-Fuchs, L Kam, R Fairhurst, S J Gange, L Goodglick, J V Giorgi, N Sidell, R Detels, and J Braun

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Townsley-Fuchs, J. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Kam, L. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Fairhurst, R. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Gange, S. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Goodglick, L. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Giorgi, J. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Sidell, N. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Detels, R. in: PubMed | Google Scholar

Department of Pathology, University of California, Los Angeles 90095-1732, USA.

Find articles by Braun, J. in: PubMed | Google Scholar

Published October 15, 1996 - More info

Published in Volume 98, Issue 8 on October 15, 1996
J Clin Invest. 1996;98(8):1794–1801. https://doi.org/10.1172/JCI118979.
© 1996 The American Society for Clinical Investigation
Published October 15, 1996 - Version history
View PDF
Abstract

HIV-1 gp120 is an immunoglobulin superantigen which can bind to preimmune serum Ig. We hypothesize that levels of such preimmune antibodies vary in the population and might affect host resistance or susceptibility to viral transmission. This study tests two predictions: (a) levels of preimmune anti-gpl20 Igs are a polymorphic trait; and, (b) these levels are correlated with resistance or susceptibility to HIV-1 transmission. The first prediction was confirmed in a longitudinal study of a low-risk seronegative population. In this group, levels of both endogenous anti-gpl20 IgM and IgG varied widely, but were characteristic and stable for each individual. The second prediction was addressed in a study of participants of the Multicenter AIDS Cohort Study, in which men "susceptible" and "resistant" to HIV infection were identified based on numbers of sexual partners and eventual seroconversion. Specimens consisted of archival sera obtained > 2 yr before seroconversion. Men in the susceptible population (low-risk seroconverters) were distinguished by low levels of anti-gpl20 IgG. We conclude that the level of preimmune anti-gpl20 IgG is a polymorphic population trait, and low levels are a potentially specific and significant factor in homosexual transmission of HIV infection.

Version history
  • Version 1 (October 15, 1996): No description
Advertisement
Advertisement