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Usage Information

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.
T J Liang, A E Reid, R Xavier, R D Cardiff, T C Wang
T J Liang, A E Reid, R Xavier, R D Cardiff, T C Wang
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Research Article

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

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Abstract

Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.

Authors

T J Liang, A E Reid, R Xavier, R D Cardiff, T C Wang

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Usage data is cumulative from March 2025 through March 2026.

Usage JCI PMC
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PDF 95 6
Citation downloads 91 0
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Total Views 610
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