Go to JCI Insight
Jci spelled out white on transparent.20160208
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews...
    • Biology of familial cancer predisposition syndromes (Feb 2019)
    • Mitochondrial dysfunction in disease (Aug 2018)
    • Lipid mediators of disease (Jul 2018)
    • Cellular senescence in human disease (Apr 2018)
    • Fibrosis (Jan 2018)
    • Glia and Neurodegeneration (Sep 2017)
    • Transplantation (Jun 2017)
    • View all review series...
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Scientific Show Stoppers
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

Jci only white

  • About
  • Editors
  • Consulting Editors
  • For authors
  • Current issue
  • Past issues
  • By specialty
  • Subscribe
  • Alerts
  • Advertise
  • Contact
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • Brief Reports
  • Technical Advances
  • Commentaries
  • Editorials
  • Hindsight
  • Review series
  • Reviews
  • The Attending Physician
  • First Author Perspectives
  • Scientific Show Stoppers
  • Top read articles
  • Concise Communication
Top
  • View PDF Adobe pdf file icon
  • Download citation information
  • Send a letter
  • License information
  • Standard abbreviations
  • Article usage
  • Citations to this article
  • Share this article
  • Need Help? E-mail the JCI
  • Top
  • Abstract
  • Version history
Advertisement

Research Article Free access | 10.1172/JCI118431

Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.

Z Zhu, W Tang, A Ray, Y Wu, O Einarsson, M L Landry, J Gwaltney Jr, and J A Elias

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Zhu, Z. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Tang, W. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Ray, A. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Wu, Y. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Einarsson, O. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Landry, M. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Gwaltney, J. in: JCI | PubMed | Google Scholar

Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA.

Find articles by Elias, J. in: JCI | PubMed | Google Scholar

First published January 15, 1996 - More info

Published in Volume 97, Issue 2 on January 15, 1996
J Clin Invest. 1996;97(2):421–430. https://doi.org/10.1172/JCI118431.
Copyright © 1996, The American Society for Clinical Investigation.

First published January 15, 1996 - Version history
Abstract

To further understand the biology of rhinovirus (RV), we determined whether IL-6 was produced during RV infections and characterized the mechanism by which RV stimulates lung cell IL-6 production. In contrast to normals and minimally symptomatic volunteers, IL-6 was detected in the nasal washings from patients who developed colds after RV challenge. RV14 and RV1A, major and minor receptor group RVs, respectively, were potent stimulators of IL-6 protein production in vitro. These effects were associated with significant increases in IL-6 mRNA accumulation and gene transcription. RV was also a potent stimulator of IL-6 promoter-driven luciferase activity. This stimulation was modestly decreased by mutation of the nuclear factor (NF)-IL-6 site and abrogated by mutation of the NF-kappa B site in this promoter. An NF-kappa B-DNA binding activity, mediated by p65, p50, and p52 NF-kappa B moieties, was rapidly induced in RV-infected cells. Activator protein 1-DNA binding was not similarly altered. These studies demonstrate that IL-6 is produced during symptomatic RV infections, that RVs are potent stimulators of IL-6 elaboration, and that RV stimulation IL-6 production is mediated by an NF-kappa B-dependent transcriptional stimulation pathway. IL-6 may play an important role in the pathogenesis of RV infection, and NF-kappa B activation is likely to be an important event in RV-induced pathologies.

Version history
  • Version 1 (January 15, 1996): No description

Article tools

  • View PDF Adobe pdf file icon
  • Download citation information
  • Send a letter
  • License information
  • Standard abbreviations
  • Article usage
  • Citations to this article
  • Share this article
  • Need Help? E-mail the JCI

Go to:

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement
Follow JCI: Facebook logo white Twitter logo v2 Rss icon
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts