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Research Article Free access | 10.1172/JCI118154

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.

C A MacRae, N Ghaisas, S Kass, S Donnelly, C T Basson, H C Watkins, R Anan, L H Thierfelder, K McGarry, and E Rowland

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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First published September 1, 1995 - More info

Published in Volume 96, Issue 3 on September 1, 1995
J Clin Invest. 1995;96(3):1216–1220. https://doi.org/10.1172/JCI118154.
© 1995 The American Society for Clinical Investigation
First published September 1, 1995 - Version history
Abstract

We have mapped a disease locus for Wolff-Parkinson-White syndrome (WPW) and familial hypertrophic cardiomyopathy (FHC) segregating in a large kindred to chromosome 7 band q3. Although WPW syndrome and FHC have been observed in members of the same family in prior studies, the relationship between these two diseases has remained enigmatic. A large family with 25 surviving individuals who are affected by one or both of these conditions was studied. The disease locus is closely linked to loci D7S688, D7S505, and D7S483 (maximum two point LOD score at D7S505 was 7.80 at theta = 0). While four different FHC loci have been described this is the first locus that can be mutated to cause both WPW and/or FHC.

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