Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Next-Generation Sequencing in Medicine (Upcoming)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI118154

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.

C A MacRae, N Ghaisas, S Kass, S Donnelly, C T Basson, H C Watkins, R Anan, L H Thierfelder, K McGarry, and E Rowland

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by MacRae, C. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Ghaisas, N. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Kass, S. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Donnelly, S. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Basson, C. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Watkins, H. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Anan, R. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Thierfelder, L. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by McGarry, K. in: JCI | PubMed | Google Scholar

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Find articles by Rowland, E. in: JCI | PubMed | Google Scholar

Published September 1, 1995 - More info

Published in Volume 96, Issue 3 on September 1, 1995
J Clin Invest. 1995;96(3):1216–1220. https://doi.org/10.1172/JCI118154.
© 1995 The American Society for Clinical Investigation
Published September 1, 1995 - Version history
View PDF
Abstract

We have mapped a disease locus for Wolff-Parkinson-White syndrome (WPW) and familial hypertrophic cardiomyopathy (FHC) segregating in a large kindred to chromosome 7 band q3. Although WPW syndrome and FHC have been observed in members of the same family in prior studies, the relationship between these two diseases has remained enigmatic. A large family with 25 surviving individuals who are affected by one or both of these conditions was studied. The disease locus is closely linked to loci D7S688, D7S505, and D7S483 (maximum two point LOD score at D7S505 was 7.80 at theta = 0). While four different FHC loci have been described this is the first locus that can be mutated to cause both WPW and/or FHC.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1216
page 1216
icon of scanned page 1217
page 1217
icon of scanned page 1218
page 1218
icon of scanned page 1219
page 1219
icon of scanned page 1220
page 1220
Version history
  • Version 1 (September 1, 1995): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts