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Usage Information

Time series prediction of plasma hormone concentration. Evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls.
K Prank, … , R D Hesch, T J Sejnowski
K Prank, … , R D Hesch, T J Sejnowski
Published June 1, 1995
Citation Information: J Clin Invest. 1995;95(6):2910-2919. https://doi.org/10.1172/JCI117998.
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Research Article

Time series prediction of plasma hormone concentration. Evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls.

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Abstract

Recent evidence links osteoporosis, a disease of bone remodeling, to changes in the dynamics of parathyroid hormone secretion. We use nonlinear and linear time series prediction to characterize the secretory dynamics of parathyroid hormone in both healthy human subjects and patients with osteoporosis. Osteoporotic patients appear to lack the periods of high predictability found in normal humans. Our results may provide an explanation for why an intermittent administration of parathyroid hormone is effective in restoring bone mass in osteoporotic patients.

Authors

K Prank, S J Nowlan, H M Harms, M Kloppstech, G Brabant, R D Hesch, T J Sejnowski

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 104 3
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Scanned page 408 15
Citation downloads 64 0
Totals 618 29
Total Views 647
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