Inhibition of leukocyte-endothelial cell interactions and inflammation by peptides from a bacterial adhesin which mimic coagulation factor X.

E Rozdzinski; J Sandros; M van der Flier; A Young; B Spellerberg; C Bhattacharyya; J Straub; G Musso; S Putney; R Starzyk

doi:10.1172/JCI117754

Laboratory of Molecular Infectious Diseases, Rockefeller University, New York 10021.

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Published in Volume 95, Issue 3 on March 1, 1995
J Clin Invest. 1995;95(3):1078–1085. https://doi.org/10.1172/JCI117754.
© 1995 The American Society for Clinical Investigation

Published March 1, 1995 - Version history

Factor X (factor ten) of the coagulation cascade binds to the integrin CD11b/CD18 during inflammation, initiating procoagulant activity on the surface of leukocytes (Altieri, D.C., O.R. Etingin, D.S. Fair, T.K. Brunk, J.E. Geltosky, D.P. Hajjar, and T. S. Edgington. 1991. Science [Wash.DC]. 254:1200-1202). Filamentous hemagglutinin (FHA), an adhesin of Bordetella pertussis also binds to the CD11b/CD18 integrin (Relman D., E. Tuomanen, S. Falkow, D.T. Golenbock, K. Saukkonen, and S.D. Wright. 1990. Cell. 61:1375-1382). FHA and the CD11b/CD18 binding loops of Factor X share amino acid sequence similarity. FHA peptides similar to Factor X binding loops inhibited 125I-Factor X binding to human neutrophils and prolonged clotting time. In addition, ETKEVDG and its Factor X analogue prevented transendothelial migration of leukocytes in vitro and reduced leukocytosis and blood brain barrier disruption in vivo. Interference with leukocyte migration by a coagulation-based peptide suggests a novel strategy for antiinflammatory therapy.

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Inhibition of leukocyte-endothelial cell interactions and inflammation by peptides from a bacterial adhesin which mimic coagulation factor X.

E Rozdzinski, J Sandros, M van der Flier, A Young, B Spellerberg, C Bhattacharyya, J Straub, G Musso, S Putney, and R Starzyk

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Inhibition of leukocyte-endothelial cell interactions and inflammation by peptides from a bacterial adhesin which mimic coagulation factor X.

E Rozdzinski, J Sandros, M van der Flier, A Young, B Spellerberg, C Bhattacharyya, J Straub, G Musso, S Putney, and R Starzyk

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