Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Aging (Upcoming)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI117565

Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis.

A J Baker, A Mooney, J Hughes, D Lombardi, R J Johnson, and J Savill

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Find articles by Baker, A. in: JCI | PubMed | Google Scholar

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Find articles by Mooney, A. in: JCI | PubMed | Google Scholar

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Find articles by Hughes, J. in: JCI | PubMed | Google Scholar

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Find articles by Lombardi, D. in: JCI | PubMed | Google Scholar

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Find articles by Johnson, R. in: JCI | PubMed | Google Scholar

Department of Medicine, University Hospital, Nottingham, United Kingdom.

Find articles by Savill, J. in: JCI | PubMed | Google Scholar

Published November 1, 1994 - More info

Published in Volume 94, Issue 5 on November 1, 1994
J Clin Invest. 1994;94(5):2105–2116. https://doi.org/10.1172/JCI117565.
© 1994 The American Society for Clinical Investigation
Published November 1, 1994 - Version history
View PDF
Abstract

Increases in mesangial cell number may herald glomerular scarring, but they are not irreversible. This study sought mechanisms by which surplus glomerular mesangial cells can be cleared. A small proportion of cultured mesangial cells exhibited typical morphological features of apoptosis (programmed cell death), which was increased by growth factor deprivation or exposure to cycloheximide, stimuli known to increase apoptosis in other cell types. Apoptosis was confirmed by typical internucleosomal chromatin cleavage. In vivo, clear morphological evidence of mesangial apoptosis leading to phagocytosis by neighboring mesangial cells was obtained in self-limited mesangial proliferation induced in rats by Thy1.1 antibody, apoptosis occurring approximately 10-fold more frequently than in the healthy rat glomerulus. Indeed, changes in glomerular cell number in Thy1.1 nephritis strongly suggested that apoptosis is the major cell clearance mechanism counterbalancing cell division, thereby mediating resolution of glomerular hypercellularity in experimental mesangial proliferation.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2105
page 2105
icon of scanned page 2106
page 2106
icon of scanned page 2107
page 2107
icon of scanned page 2108
page 2108
icon of scanned page 2109
page 2109
icon of scanned page 2110
page 2110
icon of scanned page 2111
page 2111
icon of scanned page 2112
page 2112
icon of scanned page 2113
page 2113
icon of scanned page 2114
page 2114
icon of scanned page 2115
page 2115
icon of scanned page 2116
page 2116
Version history
  • Version 1 (November 1, 1994): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts