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Research Article Free access | 10.1172/JCI117415

Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus.

K Tanaka, Y Koga, Y Y Lu, X Y Zhang, Y Wang, G Kimura, and K Nomoto

Department of Virology, Kyushu University, Fukuoka, Japan.

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Department of Virology, Kyushu University, Fukuoka, Japan.

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Department of Virology, Kyushu University, Fukuoka, Japan.

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Department of Virology, Kyushu University, Fukuoka, Japan.

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Department of Virology, Kyushu University, Fukuoka, Japan.

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Department of Virology, Kyushu University, Fukuoka, Japan.

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Department of Virology, Kyushu University, Fukuoka, Japan.

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Published September 1, 1994 - More info

Published in Volume 94, Issue 3 on September 1, 1994
J Clin Invest. 1994;94(3):1019–1025. https://doi.org/10.1172/JCI117415.
© 1994 The American Society for Clinical Investigation
Published September 1, 1994 - Version history
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Abstract

At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a single injection of anti-CD3 epsilon monoclonal antibody, mice died of interstitial pneumonitis at 24-48 h after injection, accompanied by elevation of serum levels of TNF-alpha and IFN-gamma. However, MCMV remained undetectable in the lungs during the period. Simultaneous injection of cyclosporin A reduced such effects of anti-CD3. In conclusion, although the presence of MCMV in the host may be required, MCMV-associated pneumonitis is not mediated by virus in the lung but probably by the cytokines released from T cells, of which responsiveness to stimulation via CD3 molecule has been presumably modified by MCMV infection.

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