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Research Article Free access | 10.1172/JCI117320

Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment.

D D Taub, G Tsarfaty, A R Lloyd, S K Durum, D L Longo, and W J Murphy

Clinical Services Program, Program Resources, Inc./DynCorp, Frederick, Maryland 21702-1201.

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Clinical Services Program, Program Resources, Inc./DynCorp, Frederick, Maryland 21702-1201.

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Clinical Services Program, Program Resources, Inc./DynCorp, Frederick, Maryland 21702-1201.

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Clinical Services Program, Program Resources, Inc./DynCorp, Frederick, Maryland 21702-1201.

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Clinical Services Program, Program Resources, Inc./DynCorp, Frederick, Maryland 21702-1201.

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Published July 1, 1994 - More info

Published in Volume 94, Issue 1 on July 1, 1994
J Clin Invest. 1994;94(1):293–300. https://doi.org/10.1172/JCI117320.
© 1994 The American Society for Clinical Investigation
Published July 1, 1994 - Version history
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Abstract

Recombinant human growth hormone (rhGH) promotes human T cell engraftment in mice with severe combined immunodeficiency, suggesting that rhGH may have effects on T cell adhesion and migration in vivo. The ability of rhGH to directly affect the adhesion capacity of human T cells to a variety of human or murine adhesion molecules and extracellular matrix proteins was examined. rhGH induced significant human T cell adherence to both human and murine substrates via either beta 1 or beta 2 integrin molecules. rhGH was capable of inducing significant migration of resting and activated human T cells and their subsets. Most of the migratory response to rhGH was chemokinetic rather than chemotactic. In vivo engraftment studies in severe combined immunodeficiency mice receiving human T cells revealed that treatment with rhGH resulted in improved thymic engraftment, whereas treatment with non-human-reactive ovine GH demonstrated no significant effects. These data demonstrate that rhGH directly augments human T cell trafficking to peripheral murine lymphoid tissues. rhGH appears to be capable of directly altering the adhesive and migratory capacity of human T cells to molecules of either murine or human origin. Therefore, GH may, under either isogeneic or xenogeneic conditions, play a role in normal lymphocyte recirculation.

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