Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

P Costelli; N Carbó; L Tessitore; G J Bagby; F J Lopez-Soriano; J M Argilés; F M Baccino

doi:10.1172/JCI116897

Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.

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Published in Volume 92, Issue 6 on December 1, 1993
J Clin Invest. 1993;92(6):2783–2789. https://doi.org/10.1172/JCI116897.
© 1993 The American Society for Clinical Investigation

Published December 1, 1993 - Version history

Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.

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Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

P Costelli, N Carbó, L Tessitore, G J Bagby, F J Lopez-Soriano, J M Argilés, and F M Baccino

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Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

P Costelli, N Carbó, L Tessitore, G J Bagby, F J Lopez-Soriano, J M Argilés, and F M Baccino

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