Usage Information

A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.
N J Samani, … , J Sassard, M Lathrop
N J Samani, … , J Sassard, M Lathrop
Published August 1, 1993
Citation Information: J Clin Invest. 1993;92(2):1099-1103. https://doi.org/10.1172/JCI116616.
View: Text | PDF
Research Article

A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.

Abstract

The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed SA, which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, accounting for 28 and 21% of the genetic variability in systolic and diastolic blood pressures, respectively. Further, the genotype at this locus appears to determine the level of expression of the gene in the kidney. The findings provide strong evidence for a primary genetic involvement of the kidney in hypertension.

Authors

N J Samani, D Lodwick, M Vincent, C Dubay, M A Kaiser, M P Kelly, M Lo, J Harris, J Sassard, M Lathrop

×

Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 338 8
PDF 45 7
Scanned page 172 2
Citation downloads 55 0
Totals 610 17
Total Views 627
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement